Enteric brain · Neurochemical States

Serotonin, Mood & Depletion Myths

The idea that a night of indulgence 'depletes serotonin' and leaves you compliant next morning is folk neuroscience; the real next-morning effects come from sleep loss, alcohol and hangover.

An everyday example

A team is taken to a lavish dinner with heavy drinking and then asked to sign at 8 a.m.; they are impaired, but by dehydration, poor sleep and residual alcohol.

What it can cost you

Believing a wrong mechanism means you protect against the wrong thing; the real lever is sleep and alcohol, and the fix is scheduling.

Warning signs

  • I feel flat and agreeable after a late night.
  • The meeting was scheduled right after the party.

One thing to do

Never sign the morning after a late night; move any substantive session to at least 24 hours after heavy drinking or short sleep.

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